Point of Care Patient Testing Creatinine Test

Question: Discuss about thePoint of Care Patient Testing for Creatinine Test. Answer: Introduction This report consists of the informations that are examined for the point of care device (POCT) used in the test of creatinine and troponin level in the blood of the patient. This report mainly provides the assessment of devices that are used in the test for checking the level blood troponin and blood creatinine and considering the pre analytical, analytical and post analytical effects also recommends the device which is the best for the above said test (1) . Creatinine Test The test of level of creatinine in the blood is used to determine or measure the level of blood creatinine. Creatinine is actually a waste product that is produced during the breakdown creatine (2). The human kidney normally eliminates this creatinine (3). If the kidney of any individual is not working properly then the blood creatinine level of that person will increase. Therefore the doctor uses this blood creatine level to determine the condition of the kidney (4). Recommendation of the Device The devices that are used to check the blood creatine level are i-STAT, IRMA TRUpoint, Dri-Chem 4000, Nova Statsensor, Pentra C200. Among this Nova Stat Sensor is the preferred because it is easy to handle as it is a hand held device and it is portable, the amount or volume of the sample used in this device is also small so less amount of the blood sample is taken from the patient, the sample type for the device is also whole blood which easy to collect and also the time required for the test is around 30 second which is very less in comparison to other devices. the method of detection of the sample in this device is based on enzymatic reaction and it is detected by Amperometic Biosensor which is a very relevant detection technology. The device is portable and it is hand held device also the weight of the is only 400 gm so it is very easy to carry and convenient for the patient. As the device can be taken to the patient for performing the test. Troponin Test: This test measures the level of Troponin I and Troponin T present in the blood (5). These proteins are specifically released during heart attack because the muscle of the heart gets damaged at this time. The troponin test is mainly used to confirm a heart attack has occurred(6). The greater the damaged is caused in the heart the more the amount of the release of troponin T and troponin I in the blood. Recommendation of the Device The devices which are used to test the blood troponin level are RAMP troponin I, i-Stat Troponin I, PATHFAST troponin I, Cardiac Reader troponin T, and Stratus CS troponin I. All these devices are good but the i-Stat Troponin I is preferred and recommended as the best because the type of the sample used in this device is whole blood is easy to collect from the patient also the sample volume is very less in comparison with the other devices, the volume of the sample is just 16 L, therefore it becomes quite easy to collect blood from a patient who just had a heart attack. The other devices require more amount of sample but it is hard to collect that much amount of blood from a patient who just had a heart attack. Also the method for the detection of the sample is based on ELISA and is detected by Alkaline Phosphatase Assay method which is considerably the best and a very convenient method for the detection of ELISA. Also the time required for the test is only 10 minutes which less than any other devices present so if this device is used, the result is available in a very short time. Reference Apple FS, Ler R, Murakami MM. Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. Clinical chemistry. 2012;58(11):1574-81. Romick-Rosendale LE, Legomarcino A, Patel NB, Morrow AL, Kennedy MA. Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy. Metabolomics. 2014;10(1):8-20. Hall J, Yerramilli M, Obare E, Jewell D. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. Journal of Veterinary Internal Medicine. 2014;28(6):1676-83. Devarajan P, Barasch JM. Method and kit for detecting the early onset of renal tubular cell injury. Google Patents; 2013. Andersson PO, Karlsson J-E, Landberg E, Festin K, Nilsson S. Consequences of high-sensitivity troponin T testing applied in a primary care population with chest pain compared with a commercially available point-of-care troponin T analysis: an observational prospective study. BMC research notes. 2015;8(1):1. Masson S, Anand I, Favero C, Barlera S, Vago T, Bertocchi F, et al. Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure data from 2 large randomized clinical trials. Circulation. 2012;125(2):280-8.